Phosphorus oxychloride → 4-Chloro-2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine

HRID 2183550

반응식

HRID 2183550 반응식
[CH3:1][C:2]1[N:3]=[C:4](O)[C:5]2[N:10]([CH3:11])[CH:9]=[C:8]([C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])[C:6]=2[N:7]=1.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:4]1[C:5]2[N:10]([CH3:11])[CH:9]=[C:8]([C:12]3[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[CH:14][C:13]=3[CH3:20])[C:6]=2[N:7]=[C:2]([CH3:1])[N:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178424583HCID 178424583, 화합물

생성물 1

HCID 224743134-Chloro-2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine

실험 절차

A mixture of 2,5-dimethyl-7-(2,4,6-trimethylphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol (1 mmol) in POCl3 (1.3 ml) was heated at reflux until all the starting material were consumed (about 1-3 hours). The mixture was concentrated to dryness. The residue was porued into ice-water and extracted with ethyl acetate. The organic layer was dried and concentrated to dryness to give the title compound.

후처리

  1. temperaturewas heated
  2. temperatureat reflux until all the starting material
  3. customwere consumed (about 1-3 hours)
  4. concentrationThe mixture was concentrated to dryness
  5. extractionextracted with ethyl acetate
  6. customThe organic layer was dried
  7. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-7211b86f387546a1b45600ac4ed0f29c
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900217B2

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