Water → HCID 9835604, 화합물

HRID 2183635노트

반응식

HRID 2183635 반응식
[BH4-].[Na+].[S:3]1[C:7]([C:8]2[N:9]3[CH2:17][CH2:16][N:15]=[C:10]3[S:11][C:12]=2[CH:13]=[O:14])=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2.O>CO>[S:3]1[C:7]([C:8]2[N:9]3[CH2:17][CH2:16][N:15]=[C:10]3[S:11][C:12]=2[CH2:13][OH:14])=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 22473695HCID 22473695, 화합물

생성물 1

HCID 9835604HCID 9835604, 화합물수율 37.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (0.144 g) was added in portions over 10 minutes to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]-thiazole-2-carboxaldehyde (0.73 g) in methanol (20 ml), then the mixture was stirred at ambient temperature for 2 hours and allowed to stand at ambient temperature for 18 hours. Water (35 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. The resulting solid was collected by filtration and dissolved in a 9:1 mixture of dichloromethane and ethanol (50 ml). The solution was dried (Na2SO4) and the solvents were removed in vacuo to give [3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazol-2-yl]methanol (0.275 g) as a brown solid, m.p. 138-140° C.

후처리

  1. waitto stand at ambient temperature for 18 hours
  2. stirringthe mixture was stirred at ambient temperature for 10 minutes
  3. filtrationThe resulting solid was collected by filtration
  4. dissolutiondissolved in a 9:1 mixture of dichloromethane and ethanol (50 ml)
  5. dry with materialThe solution was dried (Na2SO4)
  6. customthe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-7733cb4193ef424eb88d2cc0f11bc047
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900216B2

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