Trimethyl borate → [2-Fluoro-3-(pyridin-4-yl)phenyl]boronic acid
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.[B:14](OC)([O:17]C)[O:15]C>>[F:1][C:2]1[C:3]([C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)=[CH:4][CH:5]=[CH:6][C:7]=1[B:14]([OH:17])[OH:15]참가 물질
3
실험 절차
4-(2-Fluorophenyl)pyridine was lithiated and reacted with trimethyl borate as described in Example 31 to afford 2-fluoro-3-(pyridin-4-yl)benzeneboronic acid as a white solid: m/z (ES+) 218 (M++H).
출처 및 근거
- ORD 기록
- ord-67602589bef24acfb6b42c695597b16d
- 출처 데이터셋
- uspto-grants-2005_05
- 특허 번호
- US06900215B2
반응 노트
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