Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → N-Methyl-N-phenyl-glycine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-Methyl-N-phenyl-glycine | HCID 420843 | — |
반응 단계
The product of step 1 (1.1 g, 5.6 mmol) was dissolved in methanol (50 mL) and 1M NaOH (17 mL) added. Allow reaction mixture to stir at ambient temperature over 18 hours. 10% Citric acid solution was added until a pH=4 was reached. Extract several times with EtOAc. The organic layer was washed several times with brine, dried (Na2SO4), filtered, and concentrated affording a quantitative yield of the title compound as a yellow oil. MS (ES+) m/z 166 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06900244B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-03fbe0f0d40340a7bc7bf134029aebc9 |
| 출처 메모 | uspto-grants-2005_05 |