Cyclohexanone → Ethyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate

HRID 2184299노트

반응식

HRID 2184299 반응식
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH2:12])=[N:7][CH:6]=1)[CH3:2].[C:14]1(=O)[CH2:19]CC[CH2:16][CH2:15]1>>[NH2:11][C:9]1[C:8]2[N:7]([C:14]([CH3:19])=[C:15]([CH3:16])[N:12]=2)[CH:6]=[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:13])[CH:10]=1

참가 물질

3

반응물 2

HCID 7967CyclohexanoneHCID 9877541Ethyl 5,6-diaminonicotinate

생성물 1

HCID 9942738Ethyl 8-amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylate

반응 조건

온도
100 °C

실험 절차

To a suspension of 5,6-diamino-nicotinic acid ethyl ester (1 eq., 5.0 g) in cyclohexanone (50 ml) bromobutanone (1.4 equiv., 5.95 g) was added over 15 min. The dark brown mixture was heated to 100° C. (inner temperature) and stirred 1.5 h at this temperature. The mixture was cooled to room temperature and the light brown solid was filtered off and was washed with TBME (20 ml). Drying under reduced pressure at 45° C. Yield: 5.06 g (65%).

후처리

  1. additionwas added over 15 min
  2. temperatureThe mixture was cooled to room temperature
  3. filtrationthe light brown solid was filtered off
  4. washwas washed with TBME (20 ml)
  5. customDrying under reduced pressure at 45° C

출처 및 근거

ORD 기록
ord-8ad388311dcc40bf9016f02e0007224d
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900324B2

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