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Hydrochloric Acid → 10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid bis-(2-hydroxy-ethyl)-amide

HRID 2184477
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HRID 2184477 반응식
[OH:1][CH2:2][CH2:3][N:4]([CH2:25][CH2:26][OH:27])[C:5]([C:7]1[N:16]2[C:10]([CH2:11][N:12](C(OC)=O)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[CH2:15]2)=[CH:9][CH:8]=1)=[O:6].C(=O)([O-])[O-].[K+].[K+].Cl.[Cl-].[Na+]>CO.O>[OH:1][CH2:2][CH2:3][N:4]([CH2:25][CH2:26][OH:27])[C:5]([C:7]1[N:16]2[C:10]([CH2:11][NH:12][C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[CH2:15]2)=[CH:9][CH:8]=1)=[O:6]
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참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 11430Potassium CarbonateHCID 6979627510-(Methoxycarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid bis-(2-hydroxy-ethyl)-amide

생성물 1

HCID 6979595910,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid bis-(2-hydroxy-ethyl)-amide

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962Water용매

실험 절차

A solution of 10-(methoxycarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid bis-(2-hydroxy-ethyl)-amide (5 mmol) of Step B in methanol (50 mL) was treated with potassium carbonate and stirred at room temperature overnight. Water was then added to the solution and the pH adjusted to 6 with 6N hydrochloric acid. The solution was saturated with solid sodium chloride and extracted with dichloromethane. The combined organic layers were dried over anhydrous magnesium sulfate and evaporated to dryness to yield the title compound.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-b76a4f5fe13743a2b459a8ce55b465f9
출처 데이터셋
uspto-grants-2005_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06900200B2

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