Diiodomethane → 2-Iodo-4-methyl-5-nitropyridine

HRID 218469

반응식

[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4](N)[CH:3]=1.N(OCCC(C)C)=O.[I:20]CI>>[I:20][C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=1

참가 물질

반응물 3

HCID 6346Diiodomethane

HCID 8053Isoamyl Nitrite

HCID 2431652-Amino-4-methyl-5-nitropyridine

생성물 1

HCID 230701672-Iodo-4-methyl-5-nitropyridine수율 28%

실험 절차

To a solution of 4-methyl-5-nitro-2-pyridinamine (12 g, 78.35 mmol) in diiodomethane (100 mL) was added isoamyl nitrite (22 mL, 160.4 mmol) at rt. After stirring for 30 min, the reaction was kept at 80° C. for 2 hr. The reaction was cooled and concentrated; but most of the diiodomethane remained. The crude mixture was loaded into column directly and eluted with 10% of EtOAc in hexane, and 2-iodo-4-methyl-5-nitropyridine (5.7 g, 28%) was obtained as a yellow solid after the removal of solvents under reduced pressure.

후처리

waitthe reaction was kept at 80° C. for 2 hr
temperatureThe reaction was cooled
concentrationconcentrated
washeluted with 10% of EtOAc in hexane

출처 및 근거

ORD 기록: ord-5829d3674d8c46e8b2bcfeb6c671fdd1
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08198456B2

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