Sodium Hydroxide → 6-Iodo-4-methylpyridin-3-amine
반응식
Cl[Sn]Cl.O.[I:5][C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([N+:13]([O-])=O)=[CH:8][N:7]=1.[OH-].[Na+]>CCOC(C)=O>[I:5][C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([NH2:13])=[CH:8][N:7]=1참가 물질
5
실험 절차
To a solution of SnCl2.H2O (20.5 g, 108 mmol) in EtOAc (200 mL) was added 2-iodo-4-methyl-5-nitropyridine (5.7 g, 21.6 mmol) in EtOAc (20 mL). Heat was released, and the reaction mixture was kept at reflux for 2 hr. After cooling to rt, the reaction mixture was treated with 50% NaOH (50 mL). Solid was filtered off and washed with EtOAc. The filtrate was washed with brine, dried, and concentrated to afford 2-iodo-4-methyl-5-pyridinamine (5 g, 99%) as a yellow solid.
후처리
- temperatureHeat
- temperatureat reflux for 2 hr
- filtrationSolid was filtered off
- washwashed with EtOAc
- washThe filtrate was washed with brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-bbbbf47f9c13471fbab8bdaeb0ef81e0
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08198456B2
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