2-Acetylthiophene → beta-Dimethylamino-1-(2-thienyl)-2-propen-1-one

HRID 2184793노트

반응식

HRID 2184793 반응식
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].CO[CH:11](OC)[N:12](C)[CH3:13].[CH3:17]CCCCC>>[CH3:11][N:12]([CH3:13])[C:2](=[CH2:17])[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

참가 물질

4

반응물 3

HCID 69202-AcetylthiopheneHCID 8058HexaneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 22288452beta-Dimethylamino-1-(2-thienyl)-2-propen-1-one수율 63%

실험 절차

A mixture of 2-acetylthiophene (10.0 g, 80 mmol) (Aldrich) and dimethylformamide dimethyl acetal (15 g, 126 mmol) is refluxed under nitrogen for 3 hrs, The reaction mixture is cooled and hexane (300 mL) added. The solid is collected by filtration to yield product (1) as an orange solid (9.1 g, 50 mmol, 63%).

후처리

  1. temperatureis refluxed under nitrogen for 3 hrs
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe solid is collected by filtration

출처 및 근거

ORD 기록
ord-86743a5ccd854d649785bebd26b69f78
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399621B1

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