4-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine → 4-(4-Piperidinyl)furo[3,2-c]pyridine

HRID 2184804노트

반응식

HRID 2184804 반응식
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:5][CH2:6][CH:7]([C:10]2[C:15]3[CH:16]=[CH:17][O:18][C:14]=3[CH:13]=[CH:12][N:11]=2)[CH2:8][CH2:9]1

참가 물질

3

반응물 1

HCID 183997294-(1-Acetylpiperidin-4-yl)furo[3,2-c]pyridine

생성물 1

HCID 183997754-(4-Piperidinyl)furo[3,2-c]pyridine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2.7 g of the product obtained in Step D in 80 ml of HCl (4N) is heated at 100° C. for 12 hours and then cooled, washed with ether, and rendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution. After extraction with dichloromethane, the organic phase is dried, filtered and then evaporated to dryness enabling the expected product to be obtained.

후처리

  1. temperaturecooled
  2. washwashed with ether
  3. additionrendered basic to a pH of 10 by the addition of an aqueous sodium hydroxide solution
  4. extractionAfter extraction with dichloromethane
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customto be obtained

출처 및 근거

ORD 기록
ord-258969c5832846a0bbc19303ffe905a4
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399616B1

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