Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 2735754HCID 2735754, 화합물

생성물 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

실험 절차

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).

후처리

temperatureat reflux for 30 hours
filtrationwas filtered by suction
washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

출처 및 근거

ORD 기록: ord-b5b8d4754fe64f44b7a713d3becbb443
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06403594B1

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