1-Bromo-2-Chloroethane → 2-Chloro-5-(2-chloroethylthio)thiophene

28 cm3 of a 5N aqueous sodium hydroxide solution were added, with stirring, to a solution, cooled to a temperature in the region of 5° C., of 17.9 g of 2-chloro-5-thiophenethiol in 30 cm3 of 1-chloro-2-bromoethane, and then the temperature was allowed to return to the region of 20° C., while stirring was continued for 16 hours. The reaction mixture was diluted with 300 cm3 of ethyl acetate and washed with 3 times 150 cm3 of water. The organic solution was dried over sodium sulfate, filtered, and evaporated under reduced pressure (5 kPa) at a temperature in the region of 45° C. 20.6 g of 2-chloro-5-(2-chloroethylthio)thiophene were obtained in the form of an oil with a brown color.

1. customto return to the region of 20° C.
2. stirringwhile stirring
3. washwashed with 3 times 150 cm3 of water
4. dry with materialThe organic solution was dried over sodium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure (5 kPa) at a temperature in the region of 45° C

ORD 기록

ord-bf7f28069ecb4f838249ab7f10cf2a63

출처 데이터셋

uspto-grants-2002_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06403610B1