N-bromobutanimide → 7-Bromo-4-methoxy-2-methylsulfanylbenzooxazole

HRID 2186445

반응식

HRID 2186445 반응식
[Br:1]N1C(=O)CCC1=O.[CH3:9][O:10][C:11]1[C:16]2[N:17]=[C:18]([S:20][CH3:21])[O:19][C:15]=2[CH:14]=[CH:13][CH:12]=1>C(#N)C>[Br:1][C:14]1[C:15]2[O:19][C:18]([S:20][CH3:21])=[N:17][C:16]=2[C:11]([O:10][CH3:9])=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 224566644-Methoxy-2-(methylthio)benzo[d]oxazole

생성물 1

HCID 224566517-Bromo-4-methoxy-2-methylsulfanylbenzooxazole수율 33.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-Bromosuccinimide (2.4 g) was added to a solution of 4-methoxy-2-methylsulfanylbenzooxazole (2.63 g) in acetonitrile (80 ml) and the mixture stirred for 18 hours. It was then partitioned between dichloromethane (200 ml) and water (200 ml). The organics were washed with water (200 ml), dried over magnesium sulphate, filtered and the solvent removed in vacuo. Purification by column chromatography on silica eluting with 10% ethyl acetate in heptane afforded the title compound as a white solid (1.25 g).

후처리

  1. customIt was then partitioned between dichloromethane (200 ml) and water (200 ml)
  2. washThe organics were washed with water (200 ml)
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo
  6. customPurification by column chromatography on silica eluting with 10% ethyl acetate in heptane

출처 및 근거

ORD 기록
ord-721a3691b2b743c5ae80a1caaa429e33
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06403791B1

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