Hydrazine hydrate (1:1) → HCID 53684831, 화합물

HRID 2186500노트

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HRID 2186500 반응식
[C:1]([NH:4][CH2:5][C@H:6]([OH:13])[CH2:7][C:8](OCC)=[O:9])(=[O:3])[CH3:2].O.[NH2:15][NH2:16]>CO>[C:1]([NH:4][CH2:5][C@H:6]([OH:13])[CH2:7][C:8]([NH:15][NH2:16])=[O:9])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 54306572HCID 54306572, 화합물

생성물 1

HCID 53684831HCID 53684831, 화합물수율 84.3%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
65 °C

실험 절차

A 5.00 g (26.4 mmol) of ethyl (R)-4-acetylamino-3-hydroxybutyrate (optical purity: 95%e.e.) was dissolved in 20 ml of methanol, and 2.00 g (39.6 mmol) of hydrazine monohydrate was added thereto dropwise at room temperature. After the addition, the mixture was heated to 65° C. and then stirred overnight. After the mixture was cooled to room temperature, 20 ml of methanol was added thereto and crystallization was carried out at 10° C. to give 3.90 g (84%) of the title compound. Melting point: 177.5° C. Optical purity: >99.9%e.e.

후처리

  1. customdropwise at room temperature
  2. additionAfter the addition
  3. temperatureAfter the mixture was cooled to room temperature
  4. customcrystallization
  5. customwas carried out at 10° C.

출처 및 근거

ORD 기록
ord-cd5ab9310a684347b410a27893751429
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06403804B1

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