홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methyl iodide → 2-Benzyl-N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-benzamide

HRID 2186785
노트
인쇄 미리보기

반응식

HRID 2186785 반응식
[CH2:1]([C:8]1[CH:31]=[CH:30][CH:29]=[CH:28][C:9]=1[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[C:16]([C:24]([F:27])([F:26])[F:25])[CH:15]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][Si](C)(C)[N-][Si](C)(C)C.[K+].CI.C(OCC)(=O)C>CN(C)C=O>[CH2:1]([C:8]1[CH:31]=[CH:30][CH:29]=[CH:28][C:9]=1[C:10]([N:12]([CH2:13][C:14]1[CH:15]=[C:16]([C:24]([F:25])([F:26])[F:27])[CH:17]=[C:18]([C:20]([F:22])([F:23])[F:21])[CH:19]=1)[CH3:32])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 3251421Potassium bis(trimethylsilyl)amideHCID 98243732-Benzyl-N-(3,5-bis-trifluoromethyl-benzyl)-benzamide

생성물 1

HCID 98684212-Benzyl-N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-benzamide수율 87%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

To a solution of 100 mg (0.23 mmol) 2-benzyl-N-(3,5-bis-trifluoromethyl-benzyl)-benzamide in 1 ml N,N-dimethylformamide at 0° C. were added 50 mg (0.25 mmol) potassium hexamethyldisilazide. Stirring was continued for 1 h at this temperature and 0.016 ml (0.25 mmol) methyl iodide were added. After stirring for 3 h at room temperature, ethyl acetate was added. The mixture was washed with brine, dried (magnesium sulfate) and evaporated. The solvent was removed in vacuo and the residue was purified by flash chromatography to give 90 mg (87%) of the title compound as a colourless oil.

후처리

  1. additionwere added
  2. stirringAfter stirring for 3 h at room temperature
  3. washThe mixture was washed with brine
  4. dry with materialdried (magnesium sulfate)
  5. customevaporated
  6. customThe solvent was removed in vacuo
  7. customthe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-06075aa6fa864525aa5621d3f988052f
출처 데이터셋
uspto-grants-2002_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06407111B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트