Hydroxyamine hydrochloride → N'-Hydroxy-2-(4-methoxyphenoxy)acetimidamide
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([O:7][CH2:8][C:9]#[N:10])=[CH:5][CH:4]=1.Cl.[NH2:14][OH:15].C([O-])(=O)C.[Na+]>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([O:7][CH2:8][C:9](=[N:14][OH:15])[NH2:10])=[CH:5][CH:4]=1참가 물질
5
실험 절차
A mixture of the (4-methoxyphenoxy)acetonitrile product (5.0 g, 31 mmol) from step 1, hydroxylamine hydrochloride (4.3 g, 62 mmol) and sodium acetate (5.1 g, 62 mmol) in MeOH (100 mL) was stirred at r.t. for 2 h. The resulting mixture was filtered on Celite®, concentrated, stirred in CHCl3 for 18 h and filtered. The resulting solution was concentrated to yield (4-methoxyphenoxy)acetamide oxime as a gum.
후처리
- filtrationThe resulting mixture was filtered on Celite®
- concentrationconcentrated
- stirringstirred in CHCl3 for 18 h
- filtrationfiltered
- concentrationThe resulting solution was concentrated
출처 및 근거
- ORD 기록
- ord-3bc2afdc863840a7a0ee065412c65aa4
- 출처 데이터셋
- uspto-grants-2002_06
- 특허 번호
- US06410563B1
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