Sodium Hydroxide → cis-3-Azidomethylcyclopentancarboxylic acid

HRID 2187993노트

반응식

HRID 2187993 반응식
[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([O:12]C)=[O:11])[CH2:6]1)=[N+:2]=[N-:3].[OH-].[Na+]>>[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([OH:12])=[O:11])[CH2:6]1)=[N+:2]=[N-:3]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 86758274Methyl cis-3-azidomethylcyclopentancarboxylate

생성물 1

HCID 86758275cis-3-Azidomethylcyclopentancarboxylic acid수율 91%

실험 절차

A mixture of methyl cis-3-azidomethylcyclopentancarboxylate (1.2 g, 6.5 mmol) and 1 N sodium hydroxide (12.0 mL, 12 mmol) was stirred at room temperature for about 8 h. The alkaline mixture was extracted with chloroform. The aqueous layer was acidified with hydrochloric acid and extracted twice with chloroform. Combined chloroform extracts from the acidic mixture were dried over sodium sulfate, filtered and concentrated to give about 1.0 g (91%) of cis-3-azidomethylcyclopentancarboxylic acid.

후처리

  1. extractionThe alkaline mixture was extracted with chloroform
  2. extractionextracted twice with chloroform
  3. dry with materialCombined chloroform extracts from the acidic mixture were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3c6b04da23ea4e3a956934210c23a89d
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06410594B1

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