Acetic Anhydride → rac-(1R,3S)-3-(acetamidomethyl)cyclopentane-1-carboxylic acid

HRID 2187995노트

반응식

HRID 2187995 반응식
[NH2:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[CH3:12][C:11]([NH:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1)=[O:13]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 42614337rac-(1R,3S)-3-(aminomethyl)cyclopentane-1-carboxylic acid

생성물 1

HCID 12041173rac-(1R,3S)-3-(acetamidomethyl)cyclopentane-1-carboxylic acid수율 97%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
70 °C

실험 절차

To a mixture of cis-3-aminomethylcyclopentancarboxylic acid (0.2 g, 1.4 mmol) in pyridine (about 5 mL) was added acetic anhydride (about 1 mL) and the mixture stirred at about 70° C. for about 2 h. The solvent was removed under reduced pressure, water was added several times and evaporated in vacuo. A light, viscous oil was obtained and dried in vacuo over acetone reflux to give 0.25 g (97%) of cis-3-[(methylcarbonylamino)methyl]cyclopentancarboxylic acid.

후처리

  1. customThe solvent was removed under reduced pressure, water
  2. additionwas added several times
  3. customevaporated in vacuo
  4. customA light, viscous oil was obtained
  5. dry with materialdried in vacuo over acetone
  6. temperaturereflux

출처 및 근거

ORD 기록
ord-8b99720d62824a7bab8a81d775bd63cc
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06410594B1

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