3,4-Dichlorobenzotrifluoride → [2-Chloro-5-(trifluoromethyl)phenyl]hydrazine

HRID 2188256노트

반응식

HRID 2188256 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[Cl:8].O.[NH2:14][NH2:15]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[NH:14][NH2:15].[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([F:12])([F:11])[F:10])=[CH:3][C:2]=1[NH:14][NH2:15]

참가 물질

5

반응물 2

HCID 94813,4-DichlorobenzotrifluorideHCID 24654Hydrazine hydrate (1:1)

생성물 2

HCID 2060249[2-Chloro-5-(trifluoromethyl)phenyl]hydrazineHCID 2736687(2-Chloro-4-(trifluoromethyl)phenyl)hydrazine

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
150 °C

실험 절차

A mixture of 3,4-dichlorobenzotrifluoride (48 g), hydrazine hydrate (65 g) and pyridine (240 g) was stirred and heated at 150° C. for 6 hours in an autoclave at a pressure of 4 bar. The cooled mixture was quenched with sodium hydroxide solution and the organic layer evaporated in vacuo. The residue was dissolved in diethyl ether, washed (water) and the ether evaporated to give 2-chloro-4-trifluoromethylphenylhydrazine and 2-chloro-5-trifluoromethylphenylhydrazine as a 95/5 mixture (36 g),

후처리

  1. customThe cooled mixture was quenched with sodium hydroxide solution
  2. customthe organic layer evaporated in vacuo
  3. dissolutionThe residue was dissolved in diethyl ether
  4. washwashed (water)
  5. customthe ether evaporated

출처 및 근거

ORD 기록
ord-63687c2795ab47eba8505e66b61fc6b6
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06410737B1

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