HCID 54197900, 화합물 → HCID 69827195, 화합물

HRID 2188336노트

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HRID 2188336 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([C@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]2[C:15]([OH:17])=[O:16])=[O:8])=[CH:3][CH:2]=1>[OH-].[Na+]>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([C@@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]2[C:15]([OH:17])=[O:16])=[O:8])=[CH:3][CH:2]=1

참가 물질

3

반응물 1

HCID 54197900HCID 54197900, 화합물

생성물 1

HCID 69827195HCID 69827195, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

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온도
20 °C

실험 절차

Cis-2-(4-pyridylcarbonyl)cyclohexanecarboxylic acid was dissolved in 10% sodium hydroxide (300 mL) and stirred at 20° C. for 16 h. The aqueous solution was extracted with diethyl ether (200 mL) and then acidified to pH=4 by addition of 6 M hydrochloric acid. The resulting precipitate was collected and recrystallized from hot water, to give (1S, 2R)-2-(4-pyridylcarbonyl)cyclohexanecarboxylic acid, as a white solid (4.8 g, 40% from cis-1,2-cyclohexanedicarboxylic anhydride).

후처리

  1. extractionThe aqueous solution was extracted with diethyl ether (200 mL)
  2. additionacidified to pH=4 by addition of 6 M hydrochloric acid
  3. customThe resulting precipitate was collected
  4. customrecrystallized from hot water

출처 및 근거

ORD 기록
ord-1b29e504a58a4419927d94ed5f1c07c8
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06410781B1

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