Bromide ion → 1-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

HRID 21887노트

반응식

HRID 21887 반응식
C([Li])CCC.[Br-].[CH3:7][CH:8]([O:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1)[CH2:9][CH2:10][CH3:11].[O:21]1[CH2:25]CC[CH2:22]1>CCCCCC>[CH3:22][O:21][CH:25]=[CH:17][C:16]1[CH:19]=[CH:20][C:13]([O:12][CH:8]([CH3:7])[CH2:9][CH2:10][CH3:11])=[CH:14][CH:15]=1

참가 물질

6

반응물 4

HCID 259Bromide ionHCID 8028Tetrahydrofuran2회HCID 199306244-(1-Methylbutyloxy)benzaldehydeHCID 178418339Butyllithium

생성물 1

HCID 537267651-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphoni bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

후처리

  1. additionwas added to a solution
  2. additionwas added
  3. stirringstirring
  4. waitwas continued for two hours
  5. washThe reaction solution was washed with water
  6. dry with materialwas dried over magnesium sulfate
  7. concentrationwas then concentrated
  8. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-c98de13488664eb499e8466680457ad6
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05425897

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