Hydrazine hydrate (1:1) → 2-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)acetic hydrazide

HRID 2189033노트

반응식

HRID 2189033 반응식
O.[NH2:2][NH2:3].CO[C:6](=[O:38])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][C:15]2[C:16]3[C:23]([C:24]4[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=4)=[C:22]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[O:21][C:17]=3[N:18]=[CH:19][N:20]=2)[CH:9]=1>C1COCC1.CO>[CH3:31][O:30][C:27]1[CH:28]=[CH:29][C:24]([C:23]2[C:16]3[C:15]([NH:14][C:10]4[CH:9]=[C:8]([CH2:7][C:6]([NH:2][NH2:3])=[O:38])[CH:13]=[CH:12][CH:11]=4)=[N:20][CH:19]=[N:18][C:17]=3[O:21][C:22]=2[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:25][CH:26]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 250953893-{[5-(4-Methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester

생성물 1

HCID 582802042-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)acetic hydrazide

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
65 °C

실험 절차

Add 215 mg (4.3 mmol) of hydrazine hydrate at RT to 100 mg (0.215 mmol) of 3-{[5-(4-methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester (Example 28), dissolved in 1.5 ml of THF and 2 ml of methanol. Stir the mixture at 65° C. for 1 h and at RT overnight and then concentrate under reduced pressure. After stirring with diisopropyl ether, filter off the solid with suction and dry under reduced pressure. 89.3 mg (89.3% of theory) of the target product are obtained.

후처리

  1. concentrationat RT overnight and then concentrate under reduced pressure
  2. stirringAfter stirring with diisopropyl ether
  3. filtrationfilter off the solid with suction
  4. customdry under reduced pressure
  5. custom89.3 mg (89.3% of theory) of the target product are obtained

출처 및 근거

ORD 기록
ord-8d0423d0fb90403f996cad11d2b17268
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324222B2

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