Sodium hydride → HCID 76739653, 화합물

HRID 2189061노트

반응식

HRID 2189061 반응식
[C@H:1]1([OH:7])[CH:5]=[CH:4][C@@H:3]([OH:6])[CH2:2]1.[H-].[Na+].[C:10]([O:14][C:15](=[O:18])[CH2:16]Br)([CH3:13])([CH3:12])[CH3:11]>CN(C=O)C.C1COCC1>[C:10]([O:14][C:15](=[O:18])[CH2:16][O:6][CH:3]1[CH2:2][CH:1]([OH:7])[CH:5]=[CH:4]1)([CH3:13])([CH3:12])[CH3:11]

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 79177tert-Butyl bromoacetateHCID 10148988cis-4-Cyclopentene-1,3-Diol

생성물 1

HCID 76739653HCID 76739653, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

Dissolve 2.0 g (20 mmol) of cis-4-cyclopentene-1,3-diol in 1.5 ml of DMF and 15 ml of THF and, at 0° C., add 799 mg (60% strength, approx. 20 mmol) of sodium hydride in portions. After the end of the addition, warm the mixture to RT and stir at RT for a further 1 h, before adding 2.7 ml (18.2 mmol) of bromoacetic acid tert-butyl ester. Then stir the mixture at RT overnight. Then add water, extract with dichloromethane, wash the organic phase with satd. sodium chloride solution, concentrate under reduced pressure and dry the residue under high vacuum. Isolate the product by chromatography on silica gel (eluent: cyclohexane/ethyl acetate 5:1→2:1). 1.10 g (25.6% of theory) of the target compound are obtained.

후처리

  1. additionAfter the end of the addition
  2. stirringThen stir the mixture at RT overnight
  3. extractionThen add water, extract with dichloromethane
  4. washwash the organic phase with satd
  5. concentrationsodium chloride solution, concentrate under reduced pressure
  6. customdry the residue under high vacuum
  7. customIsolate the product by chromatography on silica gel (eluent: cyclohexane/ethyl acetate 5:1→2:1)
  8. custom1.10 g (25.6% of theory) of the target compound are obtained

출처 및 근거

ORD 기록
ord-e53ea661c1784d0d83c7b2e62c186668
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324222B2

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