Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile

HRID 2189732노트

반응식

HRID 2189732 반응식
[C:1]([C:3]1[CH:4]=[C:5](F)[CH:6]=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].O.[NH2:13][NH2:14]>>[NH:13]1[C:6]2[C:7](=[CH:10][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:8]=[N:14]1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 447549173-Fluoro-5-formylbenzonitrile

생성물 1

HCID 111263841H-Indazole-5-carbonitrile

실험 절차

5-Cyano-3-fluorobenzaldehyde (4 g, 26.8 mmol) was dissolved in hydrazine hydrate and stirred at room temperature for 18 hours. The solution was poured onto ice and the resultant solid was separated by filtration and then dried under vacuum at 60° C. to afford the title compound (1.27 g) as a pink solid. Further material was isolated from the aqueous layer. MS (ES): C8H5N3 requires 143; found 144 (MH+).

후처리

  1. additionThe solution was poured onto ice
  2. customthe resultant solid was separated by filtration
  3. customdried under vacuum at 60° C.

출처 및 근거

ORD 기록
ord-fed1136edbaf4a77ab82c1c5925cf629
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324254B2

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