Hydroxyamine hydrochloride → HCID 178471847, 화합물

HRID 2189779노트

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HRID 2189779 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2)#[N:2].C(=O)(O)[O-].[Na+].Cl.[NH2:25][OH:26]>C(O)C>[OH:26][NH:25][C:1](=[NH:2])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316705Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate

생성물 1

HCID 178471847HCID 178471847, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
50 °C

실험 절차

Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate (D47) (1 g, 4.11 mmol) was dissolved in ethanol (30 ml) and sodium bicarbonate (1.73 g, 20.55 mmol) and hydroxylamine hydrochloride (571 mg, 8.22 mmol) were added. The reaction was heated at 50° C. overnight and then allowed to cool. The reaction mixture was filtered and the residue washed with ethanol. The filtrate was evaporated to dryness in vacuo and the resultant crude title compound (1.06 g) was used the subsequent reactions.

후처리

  1. temperatureto cool
  2. filtrationThe reaction mixture was filtered
  3. washthe residue washed with ethanol
  4. customThe filtrate was evaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-88147cee73f647489fbcef919bffe2c4
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324254B2

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