Hydroxyamine hydrochloride → HCID 178471848, 화합물

HRID 2189791노트

반응식

HRID 2189791 반응식
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2].Cl.[NH2:20][OH:21].C(=O)(O)[O-].[Na+]>C(O)C>[OH:21][NH:20][C:1](=[NH:2])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316734Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate

생성물 1

HCID 178471848HCID 178471848, 화합물수율 70.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate (D96) (0.95 g, 3.91 mmol), hydroxylamine hydrochloride (1.086 g, 15.62 mmol), and sodium bicarbonate (3.28 g, 39.1 mmol), were heated in ethanol (20 ml) at 50° C. for 3 hours. The mixture was filtered and evaporated to give the title compound (760 mg) as a white powder. MS (ES): C13H16N4O3 requires 276; found (MH+) 277.

후처리

  1. filtrationThe mixture was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-117b5d196a694df08a31c9cc25167a0f
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324254B2

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