Hydrochloric Acid → Hydrochloric Acid

HRID 2189910노트

반응식

HRID 2189910 반응식
C(OC(=O)[NH:7][C@H:8]([C:10]1[N:15]=[CH:14][C:13]([F:16])=[CH:12][N:11]=1)[CH3:9])(C)(C)C.[ClH:18]>C(Cl)Cl.O1CCOCC1>[F:16][C:13]1[CH:12]=[N:11][C:10]([C@@H:8]([NH2:7])[CH3:9])=[N:15][CH:14]=1.[ClH:18]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 58367398(S)-tert-butyl 1-(5-fluoropyrimidin-2-yl)ethylcarbamate

생성물 2

HCID 313Hydrochloric AcidHCID 55285341(S)-1-(5-Fluoropyrimidin-2-YL)ethanamine

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate (Method 56, 0.21 g, 0.87 mmol) in DCM (5 ml) was added HCl (1.3 ml, 5.2 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed give (S)-1-(5-fluoropyrimidin-2-yl)ethanamine as HCl salt as white solid (quantitative). MS: Calcd.: 141. Found: [M+H]+ 142.

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-e2872520c8f443daa6abc12478dc90c4
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324252B2

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