Sodium Cyanide → 3-Benzoylpropionitrile

HRID 2189937

반응식

HRID 2189937 반응식
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].C([O-])(=O)C.[K+].[C-:17]#[N:18].[Na+]>C(O)C.O>[O:5]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][CH2:2][C:17]#[N:18]

참가 물질

6

반응물 3

HCID 8929Sodium CyanideHCID 702953-ChloropropiophenoneHCID 517044Potassium Acetate

생성물 1

HCID 1384653-Benzoylpropionitrile수율 73%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

To a solution of 3-chloro-1-phenylpropan-1-one (5.0 g, 29.7 mmol) in hot ethanol (7 mL) was added potassium acetate (2.91 g, 29.77 mmol). After cooling to room temperature, the precipitated salt was removed via filtration. To the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added sodium cyanide (2.91 g, 59.3 mmol) as a solution in water (10 mL). After stirring at room temperature for 24 hours, ethanol (30 mL) was added, and the mixture was cooled in an ice bath. The precipitate was filtered and rinsed with ethanol to provide the product (3.42 g, 73%) as fluffy white solid.

후처리

  1. customthe precipitated salt was removed via filtration
  2. customTo the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added
  3. temperaturethe mixture was cooled in an ice bath
  4. filtrationThe precipitate was filtered
  5. washrinsed with ethanol

출처 및 근거

ORD 기록
ord-2eaa63fff7b54503a240798af339fe52
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324257B2

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