Diisopropylethylamine → 1-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one

HRID 2190132노트

반응식

HRID 2190132 반응식
BrC1C=C(C([N:16]2C[CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=O)OC=1C1C=CC=C(Cl)C=1.[Br:23][C:24]1[O:28][C:27]([C:29]([OH:31])=O)=[CH:26][C:25]=1[C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([Cl:39])[CH:33]=1.C(N(CC)C(C)C)(C)C>>[Br:23][C:24]1[O:28][C:27]([C:29]([N:16]2[CH2:17][C:18](=[O:22])[NH:19][CH2:20]2)=[O:31])=[CH:26][C:25]=1[C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([Cl:39])[CH:33]=1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 580647615-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acidHCID 580647644-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one

생성물 1

HCID 580647781-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 23A and the compound from Example 35A. 5 equivalents of N,N-diisopropylethylamine are used. The product is precipitated by the addition of water to the reaction solution. The precipitate is collected by suction filtration, washed with tetrahydrofuran and dried under high vacuum. 587 mg (97% of theory) of the title compound are obtained.

후처리

  1. customThe product is precipitated by the addition of water to the reaction solution
  2. filtrationThe precipitate is collected by suction filtration
  3. washwashed with tetrahydrofuran
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-c78b9f9c63f1415fb41298c3e447049b
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324268B2

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