Acetic Acid → N-benzyl-2-(pyrimidin-2-yl)ethanamine
반응식
[CH:1]([C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1)=[CH2:2].CC(O)=O.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCO>[CH2:13]([NH:20][CH2:2][CH2:1][C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
5
실험 절차
To a solution of 2-vinylpyrimidine (1.55 g, 14.6 mmol) in EtOH (15 mL) at room temperature was added AcOH (2.0 mL) and benzylamine (3.14 g, 29.3 mmol) (3.2 mL). The reaction mixture was heated to reflux for 18 h, and concentrated. Diluted with EtOAc, washed with 5 M NaOH (1×), brine (1×), dried over MgSO4, filtered, and concentrated. Purification by flash column chromatography on silica gel (eluted with 2% to 10% MeOH in DCM) gave N-benzyl-2-(pyrimidin-2-yl)ethanamine.
후처리
- temperatureThe reaction mixture was heated
- temperatureto reflux for 18 h
- concentrationconcentrated
- additionDiluted with EtOAc
- washwashed with 5 M NaOH (1×), brine (1×)
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customPurification by flash column chromatography on silica gel (eluted with 2% to 10% MeOH in DCM)
출처 및 근거
- ORD 기록
- ord-0d326be835d64035bb0f0b90796b21bf
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08324396B2
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