Hydrochloric Acid → 3-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide

HRID 2190420노트

반응식

HRID 2190420 반응식
[N+:1]([C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=2)[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[O:13])=[CH:6][CH:5]=1)([O-])=O.O1CCCC1.Cl>CO.[C].[Pd]>[NH2:1][C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=2)[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=2)=[O:13])=[CH:6][CH:5]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 673114413-(4-nitrophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide

생성물 1

HCID 673119133-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide수율 86%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a solution of 3-(4-nitrophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide (6.75 g, 16.8 mmol) in methanol (20 mL)/tetrahydrofuran (10 mL) were added 10%-palladium carbon (2 g) and concentrated hydrochloric acid (1 mL), and the mixture was vigorously stirred under a hydrogen atmosphere at room temperature for 3 hr. The catalyst was filtered off through celite, the filtrate was concentrated under reduced pressure, and the obtained residue was triturated with diethyl ether to give the title compound (5.37 g, 86%) as a white solid.

후처리

  1. filtrationThe catalyst was filtered off through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe obtained residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-9529512fc8e541ab846eb18a9c16e42a
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324395B2

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