Bromine → HCID 86655379, 화합물

HRID 2190430노트

반응식

HRID 2190430 반응식
[NH2:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:23]=[CH:24][CH:25]=2)[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)=[O:11])=[CH:4][CH:3]=1.[S-:28][C:29]#[N:30].[K+].BrBr>>[NH2:30][C:29]1[S:28][C:3]2[CH:4]=[C:5]([O:6][C:7]3[CH:8]=[C:9]([CH:23]=[CH:24][CH:25]=3)[C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:14]=3)=[O:11])[CH:26]=[CH:27][C:2]=2[N:1]=1

참가 물질

4

반응물 3

HCID 24408BromineHCID 516872Potassium thiocyanateHCID 67312567HCID 67312567, 화합물

생성물 1

HCID 86655379HCID 86655379, 화합물수율 79.3%

실험 절차

Using 3-(4-aminophenoxy)-N-[3-(trifluoromethyl)phenyl]benzamide (2.45 g, 6.58 mmol), potassium thiocyanate (1.94 g, 20.0 mmol) and bromine (1.20 g, 7.50 mmol), and in the same manner as in Example A25(v), the title compound (2.24 g, 79%) was obtained as a pale-yellow powder.

출처 및 근거

ORD 기록
ord-6e4b2dbce74745198aab76e7a9f5addf
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324395B2

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