Hydrochloric Acid → HCID 86655402, 화합물

HRID 2190472노트

반응식

HRID 2190472 반응식
[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12]C)=[O:11])([CH3:5])[C:3]#[CH:4].CO.O.Cl>O1CCCC1>[CH3:5][C:2]([O:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([OH:12])=[O:11])([CH3:1])[C:3]#[CH:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 76333229Methyl 3-[(1,1-dimethylprop-2-yn-1-yl)oxy]benzoate

생성물 1

HCID 86655402HCID 86655402, 화합물수율 101.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 3-[(1,1-dimethylprop-2-yn-1-yl)oxy]benzoate (4.0 g, 18.3 mmol) in tetrahydrofuran (10 mL) were added lithium hydroxide•monohydrate (865 mg, 20.6 mmol), methanol (10 mL) and water (5 mL), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was adjusted to pH 3 by slowly adding 1N hydrochloric acid, and extracted with ethyl acetate (100 mL×2). The ethyl acetate layers were combined, and dried over anhydrous sodium sulfate. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (3.8 g, 99%) as a colorless oil.

후처리

  1. extractionextracted with ethyl acetate (100 mL×2)
  2. dry with materialdried over anhydrous sodium sulfate
  3. filtrationThe insoluble material was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2a1f052b16c740dd91986ce7ca1879c8
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324395B2

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