Sodium Bicarbonate → 2,7-Dibromocarbazole

HRID 219059

반응식

HRID 219059 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:9]=2N)=[C:4]([NH2:16])[CH:3]=1.C([O-])(O)=O.[Na+]>P(=O)(O)(O)O>[Br:14][C:11]1[CH:12]=[CH:13][C:8]2[C:5]3[C:4](=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=3)[NH:16][C:9]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 112215382,2'-Diamino-4,4'-dibromobiphenyl

생성물 1

HCID 111515032,7-Dibromocarbazole수율 66.2%

시약·촉매·용매 1

HCID 1004Phosphoric Acid용매

반응 조건

온도
190 °C

실험 절차

4,4′-dibromo-2,2′-diaminobiphenyl (3.5 g, 10.23 mmol) was dissolved in phosphoric acid and heated at 190° C. for 24 hours. The reaction mixture was cooled to room temperature and then NaHCO3 (aq) was gradually added thereto to form a solid. Then, the solid was filtered to obtain 2,7-dibromocarbazole (2.2 g, 66%), the compound represented by formula e. MS [M+] 323.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customto form a solid
  3. filtrationThen, the solid was filtered

출처 및 근거

ORD 기록
ord-ebd10a7ee021428fa542efc353b75e72
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198801B2

연결된 노트

불러오는 중…