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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Acetone → [2-(4,5-Dihydroxy-tetrahydro-furan-2-yl)-vinyl]phosphonic acid diethyl ester

HRID 2191012
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HRID 2191012 반응식
[CH2:1]([O:3][P:4]([CH:9]=[CH:10][CH:11]1[O:20][CH:14]2[O:15]C(C)(C)[O:17][CH:13]2[CH2:12]1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].Cl.CC(C)=O.C([O-])(O)=O.[Na+]>CC#N>[CH2:1]([O:3][P:4]([CH:9]=[CH:10][CH:11]1[CH2:12][CH:13]([OH:17])[CH:14]([OH:15])[O:20]1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]
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참가 물질

6

반응물 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 72247323[2-(2,2-Dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-vinyl]-phosphonic acid diethyl ester

생성물 1

HCID 72247331[2-(4,5-Dihydroxy-tetrahydro-furan-2-yl)-vinyl]phosphonic acid diethyl ester수율 111.8%

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

실험 절차

Compound 9.6 (3.6 g, 11.76 mmol) in MeCN (40 mL) was treated with 1 N HCl (10 mL) and stirred at 50° C. for 5 h with slow distillation of residual acetone. The solution was cooled to ambient temperature and treated with NaHCO3 (1.0 g) then concentrated in vacuo. The residue was lyophilized overnight and MeOH (20 mL) was added and the solution was filtered. The solution was then co-evaporated with MeCN to afford crude compound 9.7 (3.5 g, >100% yield).

후처리

  1. concentrationthen concentrated in vacuo
  2. additionMeOH (20 mL) was added
  3. filtrationthe solution was filtered

출처 및 근거

ORD 기록
ord-7b9d3306f13e4964962dcea6e87c1292
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08324179B2

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