Ethyl orthoformate → 5-Fluorobenzimidazole

HRID 2191924

반응식

HRID 2191924 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[CH2:10](OC(OCC)OCC)C>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]=[CH:10][NH:9][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 31214Ethyl orthoformateHCID 1645844-Fluorobenzene-1,2-diamine

생성물 1

HCID 2356985-Fluorobenzimidazole

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
150 °C

실험 절차

To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-f2ff2e146fad4178aa5667e0c91fe0c0
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329700B2

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