Sodium Hydroxide → 4-[(3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluoroaniline

HRID 2192166노트

반응식

HRID 2192166 반응식
[CH:1]1([C:4]2[C:12]3[C:7](=[N:8][CH:9]=[CH:10][C:11]=3[O:13][C:14]3[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][C:15]=3[F:24])[N:6](S(C3C=CC(C)=CC=3)(=O)=O)[CH:5]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([C:4]2[C:12]3[C:7](=[N:8][CH:9]=[CH:10][C:11]=3[O:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][C:15]=3[F:24])[NH:6][CH:5]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59740992N-[4-({3-Cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3-fluorophenyl]acetamide

생성물 1

HCID 597410174-[(3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluoroaniline

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

192 mg (0.40 mmol) of N-[4-({3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]-pyridin-4-yl}oxy)-3-fluorophenyl]acetamide are dissolved in 7 ml of ethanol. 3.5 ml of 20% strength aqueous sodium hydroxide solution are added, and the reaction mixture is stirred at 90° C. overnight. The reaction mixture is partitioned between ethyl acetate and water. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate, and the solvent is removed under reduced pressure. The crude product is reacted without further purification.

후처리

  1. customThe reaction mixture is partitioned between ethyl acetate and water
  2. extractionThe aqueous phase is extracted with ethyl acetate
  3. dry with materialThe combined organic phases are dried over sodium sulfate
  4. customthe solvent is removed under reduced pressure
  5. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-15ae91894c1b40aba01487763f9b237f
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329716B2

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