Sodium Hydroxide → 3-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}aniline

HRID 2192174노트

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HRID 2192174 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:22]C(=O)C)[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12)[NH2:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59741010N-(3-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)acetamide

생성물 1

HCID 597410123-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}aniline

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
90 °C

실험 절차

63 mg (0.18 mmol) of N-(3-fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)acetamide are dissolved in 5 ml of ethanol. 2 ml of 20% strength aqueous sodium hydroxide solution are added, and the mixture is stirred at 90° C. overnight. The reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution. The aqueous solution is extracted with ethyl acetate and the combined organic phases are washed with 1N aqueous sodium hydroxide solution. The organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure. The product is reacted further without purification.

후처리

  1. customThe reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution
  2. extractionThe aqueous solution is extracted with ethyl acetate
  3. washthe combined organic phases are washed with 1N aqueous sodium hydroxide solution
  4. dry with materialThe organic phases are dried over magnesium sulfate
  5. customthe solvent is removed under reduced pressure
  6. customThe product is reacted further without purification

출처 및 근거

ORD 기록
ord-50bf8ad04cd8421a9686db483d298bdc
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329716B2

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