Hydrochloric Acid → 4-Amino-2-chloro-6-ethylpyrimidine-5-carbonitrile

반응식

[ClH:1].[C:2]([N-:4][C:5](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH2:6][CH3:7])#[N:3].[Na+]>>[NH2:12][C:11]1[C:8]([C:9]#[N:10])=[C:5]([CH2:6][CH3:7])[N:4]=[C:2]([Cl:1])[N:3]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 86643043HCID 86643043, 화합물

생성물 1

HCID 866430424-Amino-2-chloro-6-ethylpyrimidine-5-carbonitrile

실험 절차

With stirring, 200 ml of conc. hydrochloric acid are slowly added dropwise to 37.57 g of ca. 80% strength (178.76 mmol) of sodium cyano[1-(dicyanomethylidene)propyl]-azanide such that the reaction temperature does not exceed 30° C. The reaction mixture is then added to ca. 600 ml of ice water and the solid that is formed is isolated by filtering off with suction. After drying, 33.89 g of 4-amino-2-chloro-6-ethylpyrimidine-5-carbonitrile with the melting point 226.5° C. are obtained.

후처리

customdoes not exceed 30° C
customthe solid that is formed
customis isolated
filtrationby filtering off with suction
customAfter drying

출처 및 근거

ORD 기록: ord-dd3a7ea4503a4076a039d7a2ea0f3e94
출처 데이터셋: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08329717B2

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