Sodium Hydroxide → N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea

HRID 2192221노트

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HRID 2192221 반응식
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH3:29])([CH3:28])[CH2:20]1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>CO>[CH3:28][C:21]1([CH3:29])[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:10]([NH2:9])=[S:11])[CH2:20]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 593377231-Benzoyl-3-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea

생성물 1

HCID 59337709N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 2f (60 mg, 0.149 mmol) in MeOH was added 1N NaOH (0.2 mL, 0.2 mmol). The reaction mixture was stirred at 50° C. for 2 h. The solvent was evaporated under reduced pressure and co-evaporated with toluene to afford 2g (35 mg, 80%). MS (ES) m/z 298 [M+H]+.

후처리

  1. customThe solvent was evaporated under reduced pressure and co-evaporated with toluene

출처 및 근거

ORD 기록
ord-4f5eefab415a40a694667868a81fff5a
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329718B2

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