Hydrochloric Acid → Methyl 1-phenylcycloheptanecarboxylate

반응식

[C:1]1([C:7]2([C:14]([OH:16])=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:18]O>>[CH3:18][O:15][C:14]([C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:16]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 289377231-Phenylcycloheptane-1-carboxylic acid

생성물 1

HCID 59179615Methyl 1-phenylcycloheptanecarboxylate

실험 절차

1-Phenyl-cycloheptanecarboxylic acid (Example 1c) (4.15 g) was refluxed in methanol (150 mL) and concentrated hydrochloric acid (5 mL) for 24 hours. The solvent was evaporated and the residue was dissolved in ether (100 mL) which was washed with water (100 mL), saturated sodium bicarbonate (50 mL) and water (100 mL), dried (MgSO4) and evaporated to afford the sub-titled compound (3.5 g) as an oil.

후처리

customThe solvent was evaporated
dissolutionthe residue was dissolved in ether (100 mL) which
washwas washed with water (100 mL), saturated sodium bicarbonate (50 mL) and water (100 mL)
dry with materialdried (MgSO4)
customevaporated

출처 및 근거

ORD 기록: ord-a446091158ed48bea5ddf838da65ce89
출처 데이터셋: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08329729B2

반응 노트

불러오는 중…