Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne

HRID 21923

반응식

HRID 21923 반응식
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].N1C=CN=[CH:15]1>CN(C=O)C>[O:5]([CH2:1][C:2]#[C:3][CH2:4][CH3:15])[Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 135663-Butyn-1-OLHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 110198575-(t-Butyldimethylsiloxy)-3-pentyne

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).

후처리

  1. additionThe reaction mixture was treated in the conventional manner
  2. customthe obtained crude product
  3. distillationwas distilled

출처 및 근거

ORD 기록
ord-f6de6665a81f41a69e382a42c905148e
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05426115

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