Water → 2-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

HRID 2192302노트

반응식

HRID 2192302 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[N:7][C:6]([NH2:9])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][C:20](Br)=[O:21].O>ClCCl>[Br:18][CH2:19][C:20]([NH:9][C:6]1[N:7]=[N:8][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:4][CH:5]=1)=[O:21]

참가 물질

6

반응물 4

HCID 962Water2회HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 598058596-(Trifluoromethyl)pyridazin-3-amine

생성물 1

HCID 670277332-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6-Trifluoromethyl-pyridazin-3-ylamine (0.042 g) (prepared by a procedure similar to that described in WO2007048779) was dissolved in dichloromethane (40 mL) and stirred with potassium carbonate (0.214 g). 2-Bromoacetyl bromide (0.12 mL) was added and stirring continued for 1.5 hours. Water (0.24 mL) was added and the reaction mixture was stirred for 1.5 hours after which water (40 mL) was added and the reaction mixture stirred for a further 1.5 hours. The dichloromethane was separated, dried (MgSO4) and evaporated to afford the sub-titled compound as a white solid (0.053 g).

후처리

  1. additionwas added
  2. stirringthe reaction mixture stirred for a further 1.5 hours
  3. customThe dichloromethane was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-79a9d785de3d43c5ac5f844ce979c38f
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

반응 노트

불러오는 중…