2-Methylpentane → (R)-1-(Pyridazin-3-ylcarbamoylmethyl)-3-(1-thiophen-2-yl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane bromide

HRID 2192310노트

반응식

HRID 2192310 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10]([C:12]1([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])[CH2:2]2.[Br:24][CH2:25][C:26]([NH:28][C:29]1[N:30]=[N:31][CH:32]=[CH:33][CH:34]=1)=[O:27].C(OCC)(=O)C.CCCC(C)C>C(#N)C>[Br-:24].[N:31]1[CH:32]=[CH:33][CH:34]=[C:29]([NH:28][C:26]([CH2:25][N+:1]23[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]2)[C@@H:3]([O:9][C:10]([C:12]2([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])[CH2:2]3)=[O:27])[N:30]=1

참가 물질

6

반응물 4

HCID 78922-MethylpentaneHCID 8857Ethyl AcetateHCID 574315532-Bromo-N-pyridazin-3-yl-acetamideHCID 58348375HCID 58348375, 화합물

생성물 1

HCID 44516986(R)-1-(Pyridazin-3-ylcarbamoylmethyl)-3-(1-thiophen-2-yl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane bromide수율 10.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-Thiophen-2-yl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 5d) (80 mg) and 2-bromo-N-pyridazin-3-yl-acetamide (Example 5e) (52 mg) were dissolved in acetonitrile (3 mL) and stirred overnight. Ethyl acetate (9 mL) and isohexane (4 mL) were added and stirred overnight. The resulting crystals were filtered off and then triturated with ethyl acetate to afford the titled compound (14 mg).

후처리

  1. stirringstirred overnight
  2. filtrationThe resulting crystals were filtered off
  3. customtriturated with ethyl acetate

출처 및 근거

ORD 기록
ord-c6bfc223041e4668b782e43772e947d5
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

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