2-Methylpentane → HCID 86655271, 화합물

HRID 2192313노트

반응식

HRID 2192313 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10]([C:12]1([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])[CH2:2]2.[Br:24][CH2:25][C:26]([NH:28][C:29]1[O:33][N:32]=[C:31]([CH3:34])[CH:30]=1)=[O:27].C(OCC)(=O)C.CCCC(C)C>C(#N)C>[Br-:24].[CH3:34][C:31]1[CH:30]=[C:29]([NH:28][C:26]([CH2:25][N+:1]23[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]2)[C@@H:3]([O:9][C:10]([C:12]2([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])[CH2:2]3)=[O:27])[O:33][N:32]=1

참가 물질

6

반응물 4

HCID 78922-MethylpentaneHCID 8857Ethyl AcetateHCID 133629642-Bromo-N-(3-methylisoxazol-5-yl)acetamideHCID 58348375HCID 58348375, 화합물

생성물 1

HCID 86655271HCID 86655271, 화합물수율 45.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-Thiophen-2-yl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 5d) (50 mg) and 2-bromo-N-(3-methylisoxazol-5-yl)acetamide (Example 7a) (32 mg) were dissolved in acetonitrile (2 mL) and left overnight. Ethyl acetate (10 mL) and isohexane (10 mL) were added and the crystals filtered off, washed with ethyl acetate and dried to afford the titled compound (37 mg).

후처리

  1. filtrationthe crystals filtered off
  2. washwashed with ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-85ed8045569a4562a5af4971a8928d67
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329729B2

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