2-Amino-4-methylpyridine → 2-chloro-N-(4-methylpyridin-2-yl)acetamide

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)=[O:12]

참가 물질

반응물 2

HCID 15332-Amino-4-methylpyridine

HCID 6577Chloroacetyl chloride

생성물 1

HCID 27767972-chloro-N-(4-methylpyridin-2-yl)acetamide수율 74%

실험 절차

The sub-titled compound (1.3 g, 74%, solid) was prepared by a similar procedure to that used to prepare Example 14f using 2-amino-4-methylpyridine in place of 2-amino-pyridine and adding the chloroacetyl chloride at room temperature rather than at 0° C.

후처리

customto prepare Example 14f

출처 및 근거

ORD 기록: ord-4dc351a0bfee4dca8461d3430ce5058f
출처 데이터셋: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08329729B2

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