Sodium Hydroxide → 1-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 2192484노트

반응식

HRID 2192484 반응식
[OH-].[Na+].[CH3:3][CH:4]([CH3:17])[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][C:7]1=[O:16]>CO>[CH3:3][CH:4]([CH3:17])[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][C:7]1=[O:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59214340HCID 59214340, 화합물

생성물 1

HCID 446005741-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid수율 95.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 2M aqueous solution of sodium hydroxide (5.38 ml, 10.75 mmol) was added to a solution of methyl 1-(2-methylpropyl)-2-oxo-1,2-dihydro-4-pyridinecarboxylate (D27; 0.45 g, 2.151 mmol) in methanol (10 ml). The mixture was stirred at room temperature for 2 hrs and then the solvent was removed under vacuum. The residue was taken up with water, neutralised with 2M HCl and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulphate and concentrated under vacuum to give the title compound as a white solid (400 mg).

후처리

  1. customthe solvent was removed under vacuum
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-80a094f04e5c448c801008136ebf029e
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329730B2

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