Phosphorus oxybromide → HCID 58149918, 화합물

HRID 2192494노트

반응식

HRID 2192494 반응식
P(Br)(Br)([Br:3])=O.O=[C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:17]#[N:18])[C:11]=2[CH:10]=[CH:9][NH:8]1>ClCCCl>[Br:3][C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([C:17]#[N:18])[C:11]=2[CH:10]=[CH:9][N:8]=1

참가 물질

4

반응물 2

HCID 24613Phosphorus oxybromideHCID 426091831-Oxo-1,2-dihydroisoquinoline-5-carbonitrile

생성물 1

HCID 58149918HCID 58149918, 화합물

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Phosphorus oxybromide (6.7 g) was added to a suspension of 1-oxo-1,2-dihydro-5-isoquinolinecarbonitrile (2 g) in 1,2-dichloroethane (100 ml). The resulting suspension was heated under reflux overnight. The solvent was removed in vacuo and the residue was washed with aq NaHCO3 (2N, 2×15 ml) to afford, after drying, the title compound (2.27 g). δH (DMSO-d6, 400 MHz): 7.99 (2H, m), 8.54 (3H, m).

후처리

  1. temperatureThe resulting suspension was heated
  2. temperatureunder reflux overnight
  3. customThe solvent was removed in vacuo
  4. washthe residue was washed with aq NaHCO3 (2N, 2×15 ml)
  5. customto afford
  6. customafter drying

출처 및 근거

ORD 기록
ord-1af97f074bb74f18af4b25eb8515e0bf
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329730B2

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