홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Chloroform → 7-fluoro-1-(2-(4-((naphthalen-2-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

HRID 2193339
노트
인쇄 미리보기

반응식

HRID 2193339 반응식
C(Cl)(Cl)[Cl:2].[F:5][C:6]1[CH:15]=[C:14]2[C:9]([N:10]=[CH:11][C:12](=[O:36])[N:13]2[CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([NH:24][CH2:25][C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:27]=3)[CH2:20][CH2:19]2)=[CH:8][CH:7]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:2].[F:5][C:6]1[CH:15]=[C:14]2[C:9]([N:10]=[CH:11][C:12](=[O:36])[N:13]2[CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][CH:21]([NH:24][CH2:25][C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:27]=3)[CH2:20][CH2:19]2)=[CH:8][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 21866389Hydrogen chloride-ethyl acetateHCID 593980017-fluoro-1-(2-(4-((naphthalen-2-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

생성물 1

HCID 675400997-fluoro-1-(2-(4-((naphthalen-2-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a mixed solution of 20 mL chloroform and 10 mL ethyl acetate containing 255 mg of 7-fluoro-1-(2-(4-((naphthalen-2-yl)methylamino)piperidin-1-yl)ethyl)-quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 257 mg of 7-fluoro-1-(2-(4-((naphthalen-2-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown solid.

후처리

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

출처 및 근거

ORD 기록
ord-7d65e3d70056471d8013374049c7bdf7
출처 데이터셋
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08329694B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트