Hydrochloric Acid → 3-(Pent-2-en-3-yl)-2,2'-bitiophene

HRID 2193808노트

반응식

HRID 2193808 반응식
[S:1]1[CH:5]=[CH:4][C:3]([C:6](O)([CH2:9][CH3:10])[CH2:7][CH3:8])=[C:2]1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1.Cl>C(O)(=O)C>[CH3:8][CH:7]=[C:6]([C:3]1[CH:4]=[CH:5][S:1][C:2]=1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[CH2:9][CH3:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 498402833-(2,2'-Bithiophene-3-yl)pentan-3-ol

생성물 1

HCID 679963483-(Pent-2-en-3-yl)-2,2'-bitiophene

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

3-(2,2′-bithiophene-3-yl)pentan-3-ol (IIa) (0.100 g, 0.40 mmol) was dissolved in acetic acid (69 mL). A solution of concentrated HCl (0.28 mL) in acetic acid (15 mL) was added via syringe to the reaction mixture. The solution was refluxed for 4 h followed by an extraction with chloroform, washing and drying over MgSO4. The solvent was removed in vacuo. The residue was purified by column chromatography on silica (n-Hexane). (0.070 g, 75%).

후처리

  1. temperatureThe solution was refluxed for 4 h
  2. extractionfollowed by an extraction with chloroform
  3. washwashing
  4. dry with materialdrying over MgSO4
  5. customThe solvent was removed in vacuo
  6. customThe residue was purified by column chromatography on silica (n-Hexane)

출처 및 근거

ORD 기록
ord-c408fb10b8f3415da4b6d5c154bfe0f1
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329923B2

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